Measuring Local Gradients of Intramitochondrial [Ca 2+ ] in Cardiac Myocytes During Sarcoplasmic Reticulum Ca 2+ Release
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چکیده
منابع مشابه
Measuring local gradients of intramitochondrial [Ca(2+)] in cardiac myocytes during sarcoplasmic reticulum Ca(2+) release.
RATIONALE Mitochondrial [Ca(2+)] ([Ca(2+)](mito)) regulates mitochondrial energy production, provides transient Ca(2+) buffering under stress, and can be involved in cell death. Mitochondria are near the sarcoplasmic reticulum (SR) in cardiac myocytes, and evidence for crosstalk exists. However, quantitative measurements of [Ca(2+)](mito) are limited, and spatial [Ca(2+)](mito) gradients have n...
متن کاملCa 2 1 Scraps Local Depletions of Free [ Ca 2 1 ] in Cardiac Sarcoplasmic Reticulum During Contractions Leave Substantial Ca
Free [Ca] inside the sarcoplasmic reticulum ([Ca]SR) is difficult to measure yet critically important in controlling many cellular systems. In cardiac myocytes, [Ca]SR regulates cardiac contractility. We directly measure [Ca]SR in intact cardiac myocytes dynamically and quantitatively during beats, with high spatial resolution. Diastolic [Ca]SR (1 to 1.5 mmol/L) is only partially depleted (24% ...
متن کاملCa 2 Scraps Local Depletions of Free [ Ca 2 ] in Cardiac Sarcoplasmic Reticulum
Free [Ca ] inside the sarcoplasmic reticulum ([Ca ]SR) is difficult to measure yet critically important in controlling many cellular systems. In cardiac myocytes, [Ca ]SR regulates cardiac contractility. We directly measure [Ca ]SR in intact cardiac myocytes dynamically and quantitatively during beats, with high spatial resolution. Diastolic [Ca ]SR (1 to 1.5 mmol/L) is only partially depleted ...
متن کاملCa 2 1 Scraps Local Depletions of Free [ Ca 2 1 ] in Cardiac Sarcoplasmic Reticulum During Contractions Leave
Free [Ca] inside the sarcoplasmic reticulum ([Ca]SR) is difficult to measure yet critically important in controlling many cellular systems. In cardiac myocytes, [Ca]SR regulates cardiac contractility. We directly measure [Ca]SR in intact cardiac myocytes dynamically and quantitatively during beats, with high spatial resolution. Diastolic [Ca]SR (1 to 1.5 mmol/L) is only partially depleted (24% ...
متن کاملSarcoplasmic reticulum Ca release in intact ventricular myocytes.
Sarcoplasmic reticulum (SR) Ca release in intact ventricular myocytes is the major source of Ca which activates cardiac contraction (although Ca influx makes a non-negligible contribution in most species). The fundamental events of SR Ca release are known as Ca sparks. The twitch Ca transient is composed of approximately 10,000 Ca sparks occurring in a given cell, and they are synchronized by t...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2013
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.111.300501